{
    "identifier": "ark:\/88434\/mds2-2365",
    "accessLevel": "public",
    "contactPoint": {
        "hasEmail": "mailto:jeffrey.hudgens@nist.gov",
        "fn": "Jeffrey W. Hudgens"
    },
    "programCode": [
        "006:045"
    ],
    "@type": "dcat:Dataset",
    "description": "This database gives hydrogen-deuterium exchange mass spectrometry (HDX-MS) data from measurements of three purified IgG1 glycoform samples, predominantly G0F, G2F, and SAF, in isolation and in complexation with the high-affinity receptor, Fc(gamma)RIa (CD64). The IgG1 antibody used in this study, aIL8hFc, is a murine-human chimeric IgG1, which inhibits IL-8 binding to human neutrophils. The working datasets comprise 17,750 deuterium uptake measurements in peptides from the receptor and the light and heavy chains of aIL8hFc obtained during 7 experiments, each comprising three runs of six exchange times. The data illuminate on the hydrogen exchange dynamics in isolated receptor, isolated IgG1 glycoforms, and receptor-IgG1 complexes.",
    "language": [
        "en"
    ],
    "title": "Dataset from HDX-MS Studies of IgG1 Glycoforms and Their Interactions with the Fc(gamma)RIa (CD64) Receptor",
    "distribution": [
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%239_apo-G2F_heavy_chain.CSV.sha256",
            "format": "CSV",
            "mediaType": "text\/plain",
            "title": "SHA256 File for HDX-MS data of peptides from the heavy chain of isolated (apo-)G2F IgG1 aIL8hFc."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%239_apo-G2F_heavy_chain.CSV",
            "format": "CSV",
            "description": "HDX-MS data of peptides from the heavy chain of isolated (apo-)G2F IgG1 aIL8hFc.",
            "mediaType": "text\/csv",
            "title": "HDX-MS data of peptides from the heavy chain of isolated (apo-)G2F IgG1 aIL8hFc."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%237_apo-G0F_heavy_chain.CSV.sha256",
            "mediaType": "text\/plain",
            "title": "SHA256 File for HDX-MS data of peptides from the heavy chain of isolated (apo-)G0F IgG1 aIL8hFc."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%237_apo-G0F_heavy_chain.CSV",
            "format": "CSV",
            "description": "HDX-MS data of peptides from the heavy chain of isolated (apo-)G0F IgG1 aIL8hFc.",
            "mediaType": "text\/csv",
            "title": "HDX-MS data of peptides from the heavy chain of isolated (apo-)G0F IgG1 aIL8hFc."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%235_apo-SAF_light_chain.CSV.sha256",
            "format": "CSV",
            "mediaType": "text\/plain",
            "title": "SHA256 File for HDX-MS data of peptides from the light chain of isolated (apo-)SAF IgG1 aIL8hFc"
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%235_apo-SAF_light_chain.CSV",
            "format": "CSV",
            "description": "HDX-MS data of peptides from the light chain of isolated (apo-)SAF IgG1 aIL8hFc",
            "mediaType": "text\/csv",
            "title": "HDX-MS data of peptides from the light chain of isolated (apo-)SAF IgG1 aIL8hFc"
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%231_apo-G0F_light_chain.CSV.sha256",
            "mediaType": "text\/plain",
            "title": "SHA256 File for HDX-MS data of peptides from the light chain of isolated (apo-)G0F IgG1 aIL8hFc"
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%231_apo-G0F_light_chain.CSV",
            "format": "CSV",
            "description": "HDX-MS data of peptides from the light chain of isolated (apo-)G0F IgG1 aIL8hFc",
            "mediaType": "text\/csv",
            "title": "HDX-MS data of peptides from the light chain of isolated (apo-)G0F IgG1 aIL8hFc"
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%2313_apo-FcgR1a.CSV",
            "format": "CSV",
            "description": "HDX-MS data of peptides from isolated (apo-)Fc?R1a.",
            "mediaType": "application\/vnd.ms-excel",
            "title": "HDX-MS data of peptides from isolated (apo-)Fc?R1a."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%2311_apo-SAF_heavy_chain.CSV.sha256",
            "mediaType": "text\/plain",
            "title": "SHA256 File for HDX-MS data of peptides from the heavy chain of isolated (apo-)SAF IgG1 aIL8hFc."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%2311_apo-SAF_heavy_chain.CSV",
            "format": "CSV",
            "description": "HDX-MS data of peptides from the heavy chain of isolated (apo-)SAF IgG1 aIL8hFc.",
            "mediaType": "text\/csv",
            "title": "HDX-MS data of peptides from the heavy chain of isolated (apo-)SAF IgG1 aIL8hFc."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%233_apo-G2F_light_chain.CSV",
            "format": "csv",
            "description": "HDX-MS data of peptides from the light chain of isolated (apo-)G2F IgG1 aIL8hFc",
            "mediaType": "text\/csv",
            "title": "HDX-MS data of peptides from the light chain of isolated (apo-)G2F IgG1 aIL8hFc"
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%233_apo-G2F_light_chain.CSV.sha256",
            "description": "HDX-MS data of peptides from the light chain of isolated (apo-)G2F IgG1 aIL8hFc",
            "mediaType": "text\/plain",
            "title": "SHA256 File HDX-MS data of peptides from the light chain of isolated (apo-)G2F IgG1 aIL8hFc"
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%234_holo-G2F_light_chain%28FcgR1a%29.CSV",
            "format": "CSV",
            "description": "HDX-MS data for peptides from the light chain of holo-aIL8hFc G2F glycoform in complexation with Fc(gamma)R1a.",
            "mediaType": "text\/csv",
            "title": "HDX-MS data for peptides from the light chain of holo-aIL8hFc G2F glycoform in complexation with Fc(gamma)R1a."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%2316_holo-FcgR1a%28SAF%29.CSV.sha256",
            "mediaType": "text\/plain",
            "title": "SHA256 File for HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc SAF glycoform."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%2315_holo-FcgR1a%28G2F%29.CSV.sha256",
            "mediaType": "text\/plain",
            "title": "SHA256 File for HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc G2F glycoform."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%2314_holo-FcgR1a%28G0F%29.CSV.sha256",
            "mediaType": "text\/plain",
            "title": "SHA256 File for HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc G0F glycoform."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%2315_holo-FcgR1a%28G2F%29.CSV",
            "format": "CSV",
            "description": "HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc G2F glycoform.",
            "mediaType": "text\/csv",
            "title": "HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc G2F glycoform."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%2316_holo-FcgR1a%28SAF%29.CSV",
            "format": "CSV",
            "description": "HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc SAF glycoform.",
            "mediaType": "text\/csv",
            "title": "HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc SAF glycoform."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%2314_holo-FcgR1a%28G0F%29.CSV",
            "format": "CSV",
            "description": "HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc G0F glycoform.",
            "mediaType": "text\/csv",
            "title": "HDX-MS data for peptides from (holo-)Fc(gamma)R1a in complexation with aIL8hFc G0F glycoform."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%232_holo-G0F_light_chain%28FcgR1a%29.CSV.sha256",
            "mediaType": "text\/csv",
            "title": "SHA256 File for HDX-MS data for peptides from the light chain of holo-aIL8hFc G0F glycoform in complexation with Fc(gamma)R1a ."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%232_holo-G0F_light_chain%28FcgR1a%29.CSV",
            "format": "CSV",
            "description": "HDX-MS data for peptides from the light chain of holo-aIL8hFc G0F glycoform in complexation with Fc(gamma)R1a.",
            "mediaType": "text\/csv",
            "title": "HDX-MS data for peptides from the light chain of holo-aIL8hFc G0F glycoform in complexation with Fc(gamma)R1a ."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%236_holo-SAF_light_chain%28FcgR1a%29.CSV",
            "format": "CSV",
            "description": "HDX-MS data for peptides from the light chain of holo-aIL8hFc SAF glycoform in complexation with Fc(gamma)R1a.",
            "mediaType": "text\/csv",
            "title": "HDX-MS data for peptides from the light chain of holo-aIL8hFc SAF glycoform in complexation with Fc(gamma)R1a."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%238_holo-G0F_heavy_chain%28FcgR1a%29.CSV",
            "format": "CSV",
            "description": "HDX-MS data for peptides from the heavy chain of holo-aIL8hFc G0F glycoform in complexation with Fc(gamma)R1a.",
            "mediaType": "text\/csv",
            "title": "HDX-MS data for peptides from the heavy chain of holo-aIL8hFc G0F glycoform in complexation with Fc(gamma)R1a."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%2310_holo-G2F_heavy_chain%28FcgR1a%29.CSV",
            "format": "CSV",
            "description": "HDX-MS data for peptides from the heavy chain of holo-aIL8hFc G2F glycoform in complexation with Fc(gamma)R1a.",
            "mediaType": "text\/csv",
            "title": "HDX-MS data for peptides from the heavy chain of holo-aIL8hFc G2F glycoform in complexation with Fc(gamma)R1a."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%2312_holo-SAF_heavy_chain%28FcgR1a%29.CSV.sha256",
            "mediaType": "text\/plain",
            "title": "SHA256 File for HDX-MS data for peptides from the heavy chain of holo-aIL8hFc SAF glycoform in complexation with Fc(gamma)R1a."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%238_holo-G0F_heavy_chain%28FcgR1a%29.CSV.sha256",
            "mediaType": "text\/plain",
            "title": "SHA256 File for HDX-MS data for peptides from the heavy chain of holo-aIL8hFc G0F glycoform in complexation with Fc(gamma)R1a."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%2310_holo-G2F_heavy_chain%28FcgR1a%29.CSV.sha256",
            "mediaType": "text\/plain",
            "title": "SHA256 File for HDX-MS data for peptides from the heavy chain of holo-aIL8hFc G2F glycoform in complexation with Fc(gamma)R1a."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%2312_holo-SAF_heavy_chain%28FcgR1a%29.CSV",
            "format": "CSV",
            "description": "HDX-MS data for peptides from the heavy chain of holo-aIL8hFc SAF glycoform in complexation with Fc(gamma)R1a.",
            "mediaType": "text\/csv",
            "title": "HDX-MS data for peptides from the heavy chain of holo-aIL8hFc SAF glycoform in complexation with Fc(gamma)R1a."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%236_holo-SAF_light_chain%28FcgR1a%29.CSV.sha256",
            "description": "SHA256 File for HDX-MS data for peptides from the light chain of holo-aIL8hFc SAF glycoform in complexation with Fc(gamma)R1a.",
            "mediaType": "text\/plain",
            "title": "SHA256 File for HDX-MS data for peptides from the light chain of holo-aIL8hFc SAF glycoform in complexation with Fc(gamma)R1a."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%234_holo-G2F_light_chain%28FcgR1a%29.CSV.sha256",
            "mediaType": "text\/plain",
            "title": "SHA256 File for HDX-MS data for peptides from the light chain of holo-aIL8hFc G2F glycoform in complexation with Fc(gamma)R1a."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Dataset%2313_apo-FcgR1a.CSV.sha256",
            "mediaType": "text\/plain",
            "title": "SHA256 File for HDX-MS data of peptides from isolated (apo-)Fc(gamma)R1a."
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Glossary%20of%20Protein%20Modifications.pdf.sha256",
            "mediaType": "text\/plain",
            "title": "SHA256 File for Glossary of Protein Modifications"
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Glossary%20of%20Protein%20Modifications.pdf",
            "description": "Glossary of post translational modifications present on peptides.",
            "mediaType": "application\/pdf",
            "title": "Glossary of Protein Modifications"
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Sequences%20of%20aILhFc%20and%20soluble%20FcgR1a%20%28CD64a%29.pdf.sha256",
            "mediaType": "text\/plain",
            "title": "SHA256 File for Sequences of aILhFc and soluble FcgR1a (CD64a)"
        },
        {
            "downloadURL": "https:\/\/data.nist.gov\/od\/ds\/mds2-2365\/Sequences%20of%20aILhFc%20and%20soluble%20FcgR1a%20%28CD64a%29.pdf",
            "description": "Sequences of aILhFc and soluble FcgR1a (CD64a)",
            "mediaType": "application\/pdf",
            "title": "Sequences of aILhFc and soluble FcgR1a (CD64a)"
        },
        {
            "accessURL": "https:\/\/doi.org\/10.18434\/mds2-2365",
            "title": "DOI Access for Dataset from HDX-MS Studies of IgG1 Glycoforms and Their Interactions with the Fc(gamma)RIa (CD64) Receptor"
        }
    ],
    "license": "https:\/\/www.nist.gov\/open\/license",
    "bureauCode": [
        "006:55"
    ],
    "modified": "2021-02-17 00:00:00",
    "publisher": {
        "@type": "org:Organization",
        "name": "National Institute of Standards and Technology"
    },
    "theme": [
        "Bioscience:Proteomics",
        "Chemistry:Analytical chemistry",
        "Bioscience:Biomaterials",
        "Chemistry:Molecular characterization",
        "Health:Pharmaceuticals",
        "Manufacturing:Biomanufacturing",
        "Materials:Materials characterization"
    ],
    "issued": "2021-06-03",
    "keyword": [
        "antibody-receptor interaction",
        "chromatography",
        "HDX-MS",
        "hydrogen-deuterium exchange",
        "glycosylation",
        "mass spectrometry",
        "monoclonal antibody",
        "precision",
        "peptide",
        "protein",
        "proteolysis",
        "proteomics",
        "receptor."
    ]
}