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36 results found

NMR Interlaboratory Study of NISTmAb

Data provided by  National Institute of Standards and Technology

The NISTmAb Interlaboratory NMR Study is a joint effort between 25 organizations to evaluate the performance of two-dimensional (2D) heteronuclear NMR as used to characterize the high order structure (HOS) of proteins, with the aim of harmonizing 2D-NMR methods to support industrial use of NMR as applied to mAb therapeutics. This study features nearly equal representation between laboratories from academia, government, and industry, including 4 laboratories from regulatory agencies.

Tags: NMR,biopharmaceuticals,structure,fingerprint,comparability,biosimilarity,NISTmAb,RM 8671,Biosciences and Health,interlaboratory study,harmonization,chemometrics,

Modified: 2024-02-22

Views: 0

RGTM 10169

Data provided by  National Institute of Standards and Technology

NIST developed a reference material consisting of synthetic fragments of the SARS-CoV-2 virus RNA, which is the target of molecular diagnostic tests. These RNA fragments can assist in the development and validation of RT-qPCR assays for the detection SARS-CoV-2. The RNA fragments are characterized for concentration using digital PCR methods, may be used to assess limits of detection for SARS-CoV-2 assays, and may calibrate other in-house or commercial SARS-CoV-2 controls. This dataset includes data used for RTGM 10169 SARs-Cov-2 Research Grade Test Material validation.

Tags: virus,SRM,reference material,DNA,sequencing,PCR,digital PCR,Biosciences and Health,

Modified: 2024-02-22

Views: 0

Datasets from an interlaboratory comparison to characterize a multi-modal polydisperse sub-micrometer bead dispersion

Data provided by  National Institute of Standards and Technology

These four data files contain datasets from an interlaboratory comparison that characterized a polydisperse five-population bead dispersion in water. A more detailed version of this description is available in the ReadMe file (PdP-ILC_datasets_ReadMe_v1.txt), which also includes definitions of abbreviations used in the data files. Paired samples were evaluated, so the datasets are organized as pairs associated with a randomly assigned laboratory number.

Tags: Biosciences and Health,particle,protein particle,sub-micrometer particle,subvisible particle,particle tracking analysis,resonant mass measurement,electrical sensing zone,holographic particle characterization,flow imaging,laser diffraction,flow cytometry,

Modified: 2024-02-22

Views: 0

Datasets from an interlaboratory comparison to characterize a multi-modal polydisperse sub-micrometer bead dispersion

Data provided by  National Institute of Standards and Technology

These four data files contain datasets from an interlaboratory comparison that characterized a polydisperse five-population bead dispersion in water. A more detailed version of this description is available in the ReadMe file (PdP-ILC_datasets_ReadMe_v1.txt), which also includes definitions of abbreviations used in the data files. Paired samples were evaluated, so the datasets are organized as pairs associated with a randomly assigned laboratory number.

Tags: Biosciences and Health,particle,protein particle,sub-micrometer particle,subvisible particle,particle tracking analysis,resonant mass measurement,electrical sensing zone,holographic particle characterization,flow imaging,laser diffraction,flow cytometry,

Modified: 2024-02-22

Views: 0

NIST DART-MS Forensics Database (is-CID)

Data provided by  National Institute of Standards and Technology

The NIST DART-MS Forensics Database is an evaluated collection of in-source collisionally-induced dissociation (is-CID) mass spectra of compounds of interest to the forensics community (e.g. seized drugs, cutting agents, etc.). The is-CID mass spectra were collected using Direct Analysis in Real-Time (DART) Mass Spectrometry (MS), either by NIST scientists or by contributing agencies noted per compound. The database is provided as a general-purpose structure data file (.SDF).

Tags: Standard reference data,mass spectra,Ion Fragmentation,mass spectrometry,NIST Mass Spectral Libraries,Chemical Identification,Biosciences and Health,Security and Forensics,

Modified: 2024-02-22

Views: 0

NIST DART-MS Forensics Database (is-CID)

Data provided by  National Institute of Standards and Technology

The NIST DART-MS Forensics Database is an evaluated collection of in-source collisionally-induced dissociation (is-CID) mass spectra of compounds of interest to the forensics community (e.g. seized drugs, cutting agents, etc.). The is-CID mass spectra were collected using Direct Analysis in Real-Time (DART) Mass Spectrometry (MS), either by NIST scientists or by contributing agencies noted per compound. The database is provided as a general-purpose structure data file (.SDF).

Tags: Standard reference data,mass spectra,Ion Fragmentation,mass spectrometry,NIST Mass Spectral Libraries,Chemical Identification,Biosciences and Health,Security and Forensics,

Modified: 2024-02-22

Views: 0

Aggregation of Purified Protein Reference Materials Characterized by Asymmetric Flow Field Flow Fractionation

Data provided by  National Institute of Standards and Technology

This is a file containing aggregation data for two proteins that were thermomechanically aggregated. The aggregated proteins were separated by asymmetric flow field flow fractionation and separated protein fractions were detected and quantified by UV spectrophotometry and multi-angle light scattering. The UV spectrophotometry was used to quantify the amount of residual monomer, which is reported herein. The multi-angle light scattering was fitted to a relevant model to calculate the molecular weight of the aggregated protein, also reported herein.

Tags: electrical sensing zone,flow imaging,light obscuration,particle,protein aggregate,protein particle,subvisible particle,visible particle,Biosciences and Health,

Modified: 2024-02-22

Views: 0

NIST Micronutrients Measurement Quality Assurance Program Winter and Summer 2017 Comparability Studies

Data provided by  National Institute of Standards and Technology

The Micronutrients Measurement Quality Assurance Program (MMQAP) was coordinated by the Chemical Sciences Division and supported measurement technology for selected fat- and water-soluble vitamins and carotenoids in human serum. This program was initiated in 1984 by the National Cancer Institute Division of Cancer Prevention and Control to ensure the long-term reliability of the measurements made while studying the possible cancer chemoprevention roles of these compounds.

Tags: interlaboratory comparisons,Biosciences and Health,Energy,Environment and Climate,Food and Nutrition,fat-soluble vitamins,Carotenoids,Vitamin C,Human Serum,interlaboratory study,

Modified: 2024-02-22

Views: 0

Certified values of iodine in CRMs of food matrices in mg/kg units. The uncertainties are expanded uncertainties at approximately 95% confidence.

Data provided by  National Institute of Standards and Technology

A comparison of the expanded uncertainty for certified values of iodine in food matrix CRMs. The CRMS were found by searching The European Virtual Institute for Speciation Analysis (EVISA) database using the terms "Iodine" and "Certified" in the Material category. The uncertainties are expanded uncertainties at approximately 95% confidence.

Tags: food,nutrition,dietary supplements,Standard Reference materials,reference materials,SRM,RM,Food and Nutrition,

Modified: 2024-02-22

Views: 0

SRM 2378 Fatty Acids in Human Serum

Data provided by  National Institute of Standards and Technology

Donor serum for SRM 2378 was collected from three groups of individuals: (level 1) three healthy donors who took 1000 mg/day of fish oil supplements for a minimum of one month prior to collection; (level 2) three healthy donors who took 1000 mg/day of flaxseed oil supplements for a minimum of one month prior to collection; and (level 3) three healthy donors who did not take either fish or flaxseed oil supplements for one month prior to collection.

Tags: fatty acids,serum,Biosciences and Health,

Modified: 2024-02-22

Views: 0